Dennis W
نویسنده
چکیده
It has been more than 20 years since Dr. Mattie Hendrick, a veterinary pathologist at the University of Pennsylvania, published her article titled “Postvaccinal sarcomas in the cat: Epidemiology and electron probe microanalytical identification of aluminum” in Cancer Research, first linking vaccination to sarcoma development (1). Dr. Hendrick initially brought her concerns to the forefront in 1991 in a letter to the editor of the Journal of the American Veterinary Association where they suggested a rise in sarcomas at vaccines sites may be associated with the recent enactment of a state law in Pennsylvannia requiring the rabies vaccination of cats. During the same time period of the study (1985) there was the introduction of the first Feline Leukemia vaccine which contained aluminum adjuvant and the switch from a modified live rabies vaccine to an adjuvanted killed rabies vaccine. Since then, many of Dr. Hendrick’s observations, and the studies and findings of other researchers, have matured and solidified our understanding of the etiology, the risk factors, and the incidence of vaccine-associated sarcomas in cats. Although our understanding of this condition is still incomplete I will present an overview of the current findings related to feline vaccine-associated sarcomas, their pathogenesis, and their clinical management.
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